Statistical Methods By Sp Gupta.epub [UPDATED]

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Chand Sp Gupta Statistical Methods – – Posted by: – Posted.Dissolution, in vitro bioavailability, and pharmacokinetic profile of a rotavirus vaccine single-dose oral tablet.
RotaTeq rotavirus vaccine is administered as a single-dose oral tablet (45 mg of antigen dose) to provide protective immunity against rotavirus gastroenteritis. In this study, we report the in vitro dissolution and pharmacokinetics of the rotavirus vaccine oral tablet. The dissolution rate of the oral tablet was evaluated as per US Pharmacopeia (USP) specifications (Tablets, 19th ed.). A kinetic model was also generated to describe the dissolution of the drug tablet. Two separate formulations of rotavirus vaccine were tested, containing either 0.5% (w/w) disintegrants (Crospovidone and Magnesium Stearate) or 0.75% (w/w) disintegrants (Crospovidone and Adj. Lactose), and compared with a vehicle control tablet formulation. The dissolution profiles of the 0.5% formulation with disintegrants were similar to the vehicle control formulation, but significantly faster than the 0.75% formulation with disintegrants. The dissolution profiles of the 0.75% formulation with disintegrants were similar to those of the vehicle control formulation. As expected, in vitro and in vivo bioavailability of the oral vaccine tablet were significantly higher than the vaccine in solution and in the absence of disintegrants. The robust dissolution profile and the significantly higher in vitro and in vivo bioavailability of the rotavirus vaccine oral tablet relative to the vaccine in solution or the vaccine in the absence of disintegrants, coupled with the significant increase in

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